Tripe palms
Clinical
Features
Variants
Images
Differential
Histology
Features
Variants
Images
Differential
Pathophysiology
Epidemiology
Associations
In isolation, most commonly associated with pulmonary cancer. With AN it is most commonly associated with gastric cancer.
Workup
Labs
Imaging
Diagnostic criteria
Management
Treatment
Monitoring
Counseling
Other considerations
| Tripe palms | |
|---|---|
| Specialty | Dermatology |
| Causes | Paraneoplastic syndrome[1] |
| Diagnostic method | Appearance[1] |
| Frequency | Rare[1] |
Tripe palms, also known as acanthosis palmaris, is a medical sign characterized by thick ridged velvety palms, typically as part of a paraneoplastic syndrome.[1] It resembles the lining of the stomach of some animals (tripe).[2] Other signs that may be noted at the same time include most frequently acanthosis nigricans (AN), and less commonly finger clubbing and Leser-Trélat sign.[2]
The sign is rare.[3]
Signs and symptoms
Tripe palms appear as thick ridged velvety palms, typically as part of a paraneoplastic syndrome.[1]
Cause and mechanism
How it occurs is unclear.[3] More than 90% of individuals with the sign have a cancer.[1][2] In some, both tripe palms and AN appear together before the cancer is diagnosed.[3] Lung cancer is more frequent if the tripe palms present alone, whereas cancer of the stomach is more frequent when AN is also present.[1] The sign has also been associated with bullous pemphigoid, psoriasis, and exfoliative dermatitis.[2] It is believed that growth factors secreted by cancer cells cause some skin cells to grow.[3]
Diagnosis and treatment
Diagnosis is by its appearance and a biopsy is generally not helpful.[2] Other conditions that may appear similar include acromegaly, acrokeratosis paraneoplastica, hypertrophic osteoarthropathy, idiopathic hypertrophic osteoarthropathy, palmoplantar keratoderma, and acropachy.[2] Tripe palms may improve with treatment of the underlying cancer.[3]
Epidemiology
The sign is rare.[3] There are around 100 reported cases worldwide.[2]
History
The term was first coined by Jacqueline Clarke in 1977.[4][5]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "24. Endocrine diseases". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Elsevier. p. 503. ISBN 978-0-323-54753-6.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Tripe Palms - DermNet". dermnetnz.org. Retrieved 1 August 2023.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Fonia, Athina; Baran, Robert (2021). "Cutaneous paraneoplastic syndromes with nail involvement". In Lipner, Shari (ed.). Nail Disorders: Diagnosis and Management, An Issue of Dermatologic Clinics. Elsevier. p. 179. ISBN 978-0-323-70924-8.
- ↑ Clarke, Jacqueline (June 1977). "Malignant acanthosis nigricans". Clinical and Experimental Dermatology. 2 (2): 167–170. doi:10.1111/j.1365-2230.1977.tb01561.x. PMID 884896.
- ↑ Niederhuber, John E. (1993). Current Therapy in Oncology. B.C. Decker. ISBN 978-1-55664-229-6.
